Can This Pill Stop Hangovers? | Last Call Founders on Mindful Drinking, DHM & Better Mornings

Behind the Pour

Teddy and Sampson have been friends since high school. They are also the founders of Last Call, a supplement built around DHM — dihydromyricetin, a compound derived from the Japanese raisin tree that has been used in Korean and Japanese traditional medicine for centuries as a support for alcohol metabolism. Their tagline is 'A better morning starts tonight.' Crystal sits down with them for a conversation about whether 'drink smarter' is a real category shift or another wellness marketing trend — and comes out with a more nuanced answer than she expected.

What You'll Discover

• What DHM is and how it works: Dihydromyricetin (DHM) is a plant-derived flavonoid that research suggests supports the enzyme systems responsible for metabolizing alcohol in the liver. It has been used in Korean and Japanese traditional medicine for this purpose for centuries. Last Call uses it as the primary active compound.
• The Korean inspiration behind the formula: Korean drinking culture has a long tradition of taking supplements before or after drinking — the hangover supplement category is well-established in Asia, where products like Condition (Korea) and Ukon no Chikara (Japan) have mainstream retail presence. Last Call is bringing that approach to the American market.
• You take it before bed, not the next morning: The timing matters. DHM works with your body's overnight recovery process — taking it before sleep gives the compound time to support metabolism while you rest. Teddy and Sampson take it even for 1–2 drinks.
• It is not a cure — it is health-conscious drinking: Teddy is explicit that Last Call is not positioned as a license to drink more. It is a supplement for people who drink intentionally and want to support their body's recovery. Crystal connects this to the broader mindful drinking conversation.
• Future forms in development: Gummies and mints are in the product roadmap — portable formats that make the take-before-bed ritual more accessible for social settings.

A Moment of Pourspective

Drinking to remember is the TLC philosophy. Part of remembering is waking up able to reflect on what you tasted. A supplement that supports your recovery is not a workaround — it is consistency with your own values.

Explore the Conversation

The Last Call episode sits at the intersection of two trends that Crystal and Roger take seriously: mindful drinking and spirits education. Teddy and Sampson's background as high school friends who built a company together gives the conversation personal warmth alongside the product pitch. Crystal's vision for alcohol education is the episode's most expansive moment. She describes what TLC is building — a culture where people understand what they are drinking, why they are drinking it, and how to support their body through the experience. Last Call fits that vision in a specific way: it is a product that reinforces the idea that you can drink with intention and also take care of yourself. The Gen Z connection Teddy makes is consistent with the broader Rohan Duggal episode: younger drinkers are choosing better products less frequently, which means each occasion matters more. A supplement that supports a better morning is aligned with that approach to drinking.

Frequently Asked Questions

• Is Last Call FDA approved? Dietary supplements in the United States do not require FDA approval before going to market. Last Call is classified as a supplement, not a pharmaceutical. Consult a healthcare professional if you have specific health questions.
• When do you take it? Last Call is designed to be taken before bed, after drinking, to support overnight alcohol metabolism. Teddy and Sampson recommend taking it even for light drinking occasions.
• What is DHM? Dihydromyricetin (DHM) is a flavonoid extracted from the Japanese raisin tree (Hovenia dulcis). It has been studied for its effects on alcohol metabolism and has a long history of use in Asian traditional medicine for post-drinking support.
• Where can I buy Last Call? Available at their website and on Amazon with Prime shipping at time of recording.

Episode at a Glance

• Guests: Teddy and Sampson (founders, Last Call)
• Host: Crystal
• Runtime: 21 minutes, 3 seconds
• Category: Spirits Education
• Topic: DHM supplement for hangover prevention and mindful drinking